Further studies on human enteric coronaviruses

Epidemiologic studies on human enteric viruses in Cameroon

Antigenic and genomic relationships among turkey and bovine enteric coronaviruses.

Antigenic and genomic relationships among tissue culture-adapted turkey enteric coronavirus (TCV) isolates, three strains of avian infectious bronchitis virus (IBV), and mammalian coronaviruses were investigated. Immunoblotting and immunoprecipitation experiments using polyclonal antisera showed that the four major structural proteins of TCV cross-reacted with the four homologous proteins of bo...

Further studies on polyribophosphate.

In previous reports (2, 3) it has been demonstrated that the type-specific substance of Hernophilus injluenzae, type b, is a polymer of ribose and phosphate, i.e. a polyribophosphate. Similar to ribonucleie acid, PRPI consists of a long chain of ribose units connected by 3,5-phosphate diester linkages. However, instead of a purine or pyrimidine on carbon 1 of ribose, as is the case in ribonucle...

Further Studies on Sympathetic

A second investigation into sympathetic detonation of ammonium nitrate (AN) and ammonium nitrate-fuel oil (ANFO) was conducted to define the scaling law for safe separation from detonating ANFO. Both missileand non-missile-producing ANFO donors weighing up to 5,400 pounds were employed with equal sizedacceptors. The usual cube root scaling law was not confirmed; exponents for the relationship S...

Inhibitory effects of recombinant human cystatin C on human coronaviruses.

Cystatin C, a potent inhibitor of cysteine proteases such as papain and cathepsin B, was examined for its effect on human coronaviruses OC43 and 229e. Both viruses were greater than 99% inhibited by 0.1 mM inhibitor. Endpoint titrations showed that inhibiting activity paralleled that of leupeptin, a serine and cysteine protease inhibitor, and indicated that 1 to 2 microM inhibitor, slightly abo...